Endocrine Abstracts

Background and aim: There is an increasing use of computed tomography (CT) scans with an iodine-based contrast medium. Last year, a large University Hospital in Denmark performed 50 000 CT scans where each injection contained between 3500 and 7000 μg free iodine corresponding to 23–45 times normal daily intake. We wished to investigate if patients with newly diagnosed hyperthyroidism had been exposed to an iodine based CT scan within 1 year prior to symptoms of hyper...

Background: Polycystic ovary syndrome (PCOS) is clinically associated with increased risk of CVD. Thrombin generation (TG) is a measure of the thrombotic potential. This can be expressed as endogenous thrombin potential (ETP) representing the total amount of generated active thrombin over the time (nmol/l×min). ETP is considered the most predictive parameter of thrombosis and is associated to both venous and arterial thrombotic disease. Setting: PCOS women prospectively r...

Background: The growth hormone system (growth hormone, GH and insulin-like-growth-factor I, IGF-I) might be implicated in congestive heart failure (CHF). In experimental models IGF-I increases cardiac contractility and reduces apoptosis of myocytes exposed to ischemic injury. In clinical studies GH-therapy has been used in CHF. One previous population based investigation showed that low levels of IGF-I was associated with an increased incidence of CHF. The result of this inves...

Objective: Untreated overt hyperthyroidism is known to predispose the patient to cardiovascular diseases, while predisposition in subclinical hyperthyroidism has been debated. The1 cut-off point of TSH for initiating treatment in subclinical hyperthyroidism is still undefined.Method: A community-based prospective study including non-hospitalised participants, aged 51 to 91 years, living in Copenhagen, Denmark were examined between September 1998 and Janu...

Endocr Connect 2015 vol. 4 no. 1 37–42. DOI: 10.1530/EC-14-0137...

Background: Polycystic ovary syndrome (PCOS) is according to the Rotterdam criteria defined as minimum two of: oligomenoré, hyperandrogenism and polycystic ovary. These criteria do not take into account PCOS’ association with the metabolic syndrome (MES) and ischaemic heart disease (IHD). Recently we grouped PCOS- patients into four phenotypes depending on normal/high BMI and insulin resistance (IR). We demonstrated that PCOS-patients with high BMI and increased IR h...

Background: Subclinical hypothyroidism is associated with a number of cardiovascular risk factors such as hypertension, hypercholesterolemia, and diastolic dysfunction, but only limited data exist on long-term outcome of levothyroxine substitution therapy.Objectives: To examine effects of levothyroxine substitution treatment on mortality in patients with subclinical hypothyroidism.Study design: Historical cohort study.<p class=...

Background and aim: Low T3 syndrome is associated with a poor prognosis in patients with chronic heart failure (CHF). It is controversial whether T3 treatment is indicated in CHF. A previous study using intravenous infusion of T3 for 72 h suggested a beneficial effect on cardiac performance.We aimed to evaluate the effect of 13 weeks of T3 treatment in patients with stable CHF on left ventricular ejection fraction (LVEF) compared to placebo.<p class=...

ESE Young Investigator AwardBackground: It is still discussed if subclinical hyperthyroidism and ‘high-normal’ thyroid function are risk-factors for cardiovascular mortality.Objectives: To examine the risk of cardiovascular and all-cause mortality in relation to subclinical hyperthyroidism.Methods: Patients consulting their general practitioner from 2000 to 2009 in Copenhagen, Denmark, who ...

Introduction: Hypothyroidism has detrimental effects on the cardiovascular system but controversy remains over the benefit of levothyroxine substitution in heart failure (hf). The aim of this register based cohort study was to examine the effects of levothyroxine treatment on all-cause mortality in patients with hf.Methods: The study cohort comprised all Danish citizens aged ≥18 years admitted with hf in 1997–2012 and still alive 30 days after...